Tempo-iOligo™
Human iPSC-derived Oligodendrocyte Progenitor Cells (OPCs)
Tempo-iOligo™
Human iPSC-derived Oligodendrocyte Progenitor Cells (OPCs)
Oligodendrocytes belong to the family of glial cells in the human central and peripheral nervous system. They are multifunctional cells and are implicated in many disabling neurological disorders, including adult-onset demyelinating disorders, as well as leukodystrophies and cerebral palsy.
Tempo’s iOligo™ cells are induced oligodendrocyte progenitors reprogrammed from human fibroblasts cells using a proprietary reprogramming technology. Tempo-iOligo™ cells are characterized using standard methods to evaluate morphology and biomarker expressions. Immunocytochemistry methods can be used to evaluate known marker proteins (such as O4, PDGFalphaR, NG2, and CNPase). The iOligo™ cells can be induced to express MBP upon T3 hormone induction.
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Applications
Tempo-iOligo™ are intended for basic scientific research, drug discovery and therapeutics development use only. It is not a product for human testing or diagnostics.
Phenotypic Assays
High Content Imaging
Biomarker Discovery
Cytotoxicity Assays
Target Validation
Lead Optimization
Investigative Toxicology
Nonclinical Efficacy Evalutions
Live-cell Imaging
2D & 3D Cell Culture
Biomarker Authentication
Tempo’s “Build an organoid” is easy to scale!
Ready in DAYS NOT WEEKS, and simplifies assay and data analysis.
iOligo, iMG
ratio to 6:1, 3:1, 4:1
Specifications
>0.5×10^6 cells per 1ml of freezing medium (vial)
Long-term Storage: liquid nitrogen
Growth Properties: adherent
Storage: remove cryovials (dry ice packaging) and place the vial into liquid nitrogen for storage. Alternatively, thaw and use the cells immediately.
Technology used: an in-house developed proprietary non-viral, nucleic-acids-free, feeder-free, serum-free, and integration-free reprogramming technology.
QC: Sterility, Safety (BioSafety Level 2), HIV/viruses, bacteria, fungi: negative. Cell viability post-thawing (>90%)
Tempo-iOligo™ SKU102