by Karen O'Hanlon Cohrt | Oct 1, 2018 | Trends
Gene reporter assays have contributed hugely to our understanding of how genes are regulated during growth and development, for example, through the study of spatiotemporal gene expression patterns, as well as how gene expression is regulated by transcription factors,...
by Karen O'Hanlon Cohrt | Oct 22, 2018 | Trends
Genetically Encoded Biosensors for Research and Drug Discovery Mitochondrial integrity and function are pivotal to cellular energy production, and mitochondrial dysfunction has been shown to alter the cell cycle, metabolism, cell viability, gene regulation, and other...
by Karen O'Hanlon Cohrt | Jan 16, 2019 | Trends
Welcome back to the drug discovery series! In this post, we journey through target validation and assay development and validation for compound screening! Target Validation As mentioned earlier in the series, most small molecule drugs function by modulating the...
by Karen O'Hanlon Cohrt | Sep 10, 2018 | Trends
Welcome back to our small molecule drug development series! If you’re only joining us now, check out our introductory article to drug discovery. Otherwise let’s dive straight into the world of drug target identification! So, What Is a Drug Target? In the world of drug...
by Karen O'Hanlon Cohrt | Jul 16, 2018 | Trends
The world of drug discovery is rife with new approaches within immunotherapy (e.g., T cell-based cancer therapies), personalized vaccines, microbiome therapies, and CRISPR-based therapies in an attempt to provide novel treatments and cures for a wide range of...