by Allison Kennedy | Jun 26, 2023 | Disease Models
Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between the blood and hepatocytes. They are the most abundant non-parenchymal hepatic cell population. LSECs play an important role in physiological,...
by Karen O'Hanlon Cohrt | Sep 24, 2023 | Disease Models
In our last few liver articles, we highlighted the urgent need for new models and treatments for non-alcoholic steatohepatitis (NASH), and looked at the potential for human liver organoids to not only model disease, but also to test new drugs for safety and efficacy....
by Karen O'Hanlon Cohrt | Jul 18, 2023 | Disease Models
The lack of approved treatments for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatosis (NASH) is largely explained by the shortcomings of cellular models used to unravel disease mechanisms, identify and validate new drug targets, and screen...
by Olwen Reina | Mar 4, 2016 | Disease Models
Microglia have been studied extensively for their role in various neurodegenerative diseases and brain injuries, including Alzheimer’s disease, Parkinson’s disease, Epilepsy, Frontal Temporal dementias, Amyotrophic Lateral Sclerosis (ALS), ischemic injury, and...
by Olwen Reina | Apr 4, 2016 | Disease Models
Hepatocytes are widely used to screen potential drug candidates and have allowed researchers to fast-track many new treatments into clinical trials. Quickly releasing new drug treatments that meet the high standards called for by patients and doctors is an immense...
by Olwen Reina | Apr 21, 2016 | Disease Models
A xenograft (or heterograft) is a piece of living tissue taken from a donor of one species and grafted into a recipient of different species. Cancer refers to a group of diseases characterized by uncontrolled division of abnormal cells in a part of the body. According...
