by Karen O'Hanlon Cohrt | Apr 9, 2025 | Disease Models
In a previous Cell of The Month article, we explored the biology of the kidney. We highlighted the structure and function of the glomerulus podocytes and proximal tubules; these are specialized cell types found in the nephron, which is the kidney’s key structural and...
by Karen O'Hanlon Cohrt | Feb 4, 2025 | Cell Culture Techniques, Disease Models
Induced pluripotent stem cells (iPSCs) have become a mainstay in disease modeling and drug development, offering almost unlimited opportunities to study human biology in the lab. However, working with these cells can present hurdles that catch even the most seasoned...
by Karen O'Hanlon Cohrt | Dec 9, 2024 | Disease Models
Welcome back to our Cell of the Month series! This time, we are talking about Kupffer cells – what they are, what they do, and why we should want to learn more about them! Kupffer cells – the gatekeepers of the liver First described by German anatomist...
by Karen O'Hanlon Cohrt | May 27, 2024 | Disease Models
Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells. First discovered and named almost 200 years ago by German pathologist...
by Karen O'Hanlon Cohrt | Apr 4, 2023 | Disease Models
This article was originally published on 4th April 2023. It was revised and republished on 19th March 2023, to reflect important updates in the NASH therapeutic development space, including FDA approval of Rezdiffra in March 2024. Welcome to our new mini-series about...
by Karen O'Hanlon Cohrt | Dec 26, 2023 | Disease Models
It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...
