by Karen O'Hanlon Cohrt | Nov 18, 2022 | Trends
Welcome to our new blog series about the blood brain barrier (BBB)! In Part 1, we will give a brief history on the discovery of the BBB, as well as introduce what we know about its composition and biological functions. The blood brain barrier or BBB is a highly...
by Karen O'Hanlon Cohrt | Mar 22, 2019 | Disease Models
Welcome back to our cell of the month series. This time we’re talking about CD34+ cells, a type of undifferentiated multipotent hematopoetic stem cell (HSC) with the potential to differentiate into almost any other blood cell type under specific conditions. As stem...
by Karen O'Hanlon Cohrt | Feb 22, 2019 | Disease Models
Most of us will remember from high school biology class that kidneys comprise part of the excretory system and function in toxin removal, maintaining electrolyte homeostasis and regulating the body’s acid-base balance. Beyond this, proper kidney function is also...
by Karen O'Hanlon Cohrt | Jan 16, 2019 | Trends
Welcome back to the drug discovery series! In this post, we journey through target validation and assay development and validation for compound screening! Target Validation As mentioned earlier in the series, most small molecule drugs function by modulating the...
by Karen O'Hanlon Cohrt | Dec 17, 2018 | Industry News
The increasing complexity of novel therapies calls for disease models that take us closer than ever before to the in vivo situation, to maximize efficacy and safety evaluations of new experimental treatments. Significant improvements in our understanding of mammalian...
