by Karen O'Hanlon Cohrt | Feb 22, 2019 | Disease Models
Most of us will remember from high school biology class that kidneys comprise part of the excretory system and function in toxin removal, maintaining electrolyte homeostasis and regulating the body’s acid-base balance. Beyond this, proper kidney function is also...
by Karen O'Hanlon Cohrt | Jan 16, 2019 | Trends
Welcome back to the drug discovery series! In this post, we journey through target validation and assay development and validation for compound screening! Target Validation As mentioned earlier in the series, most small molecule drugs function by modulating the...
by Karen O'Hanlon Cohrt | Dec 17, 2018 | Industry News
The increasing complexity of novel therapies calls for disease models that take us closer than ever before to the in vivo situation, to maximize efficacy and safety evaluations of new experimental treatments. Significant improvements in our understanding of mammalian...
by Karen O'Hanlon Cohrt | Oct 22, 2018 | Trends
Genetically Encoded Biosensors for Research and Drug Discovery Mitochondrial integrity and function are pivotal to cellular energy production, and mitochondrial dysfunction has been shown to alter the cell cycle, metabolism, cell viability, gene regulation, and other...
by Karen O'Hanlon Cohrt | Oct 1, 2018 | Trends
Gene reporter assays have contributed hugely to our understanding of how genes are regulated during growth and development, for example, through the study of spatiotemporal gene expression patterns, as well as how gene expression is regulated by transcription factors,...
