Cell-based models for human diseases

Cell-based assay technology reagents

Tempo-iOligo™: Major study identifies TMEFF1 as a critical factor for HSV-1 replication in the central nervous system

Tempo-iOligo™was cited in Nature in a major infectious disease study that offers the first explanation as to why herpes simplex virus 1 (HSV-1) infection in the brain is very rare, despite the fact that most of us have been infected with the virus. The study used CRISPR screens to find new factors involved in controlling HSV-1 replication in the brain, and found that depletion of the transmembrane protein TMEFF1 in human neurons and in mice led to increased viral replication and neuronal death following HSV-1 infection.  Tempo’s iOligo cells are induced oligodendrocyte progenitors reprogrammed from human skin fibroblasts using Tempo’s proprietary reprogramming technology. While...

Cell of the Month: Mast Cells

Mast cells are tissue-resident immune cells derived from the myeloid lineage, and along with basophils, eosinophils and neutrophils, they belong to the granulocyte family of white blood cells.  First discovered and named almost 200 years ago by German pathologist...

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Cell of the Month: Pericytes

It’s a fibroblast-like cell adorned with long cytoplasmic processes that wrap around the endothelial cells in blood vessels, it controls blood flow through the blood vessels, and it is essential for normal brain function and development. Which cell type is it? Well,...

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The Promises and Problems with ADCs

Antibody drug conjugates (ADCs) are targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. In contrast to conventional chemotherapies, which do not discriminate between healthy and cancerous cells, ADCs are...

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Tempo Bioscience Services

Disease Models and Assay Services

Tempo offers services and alliances based on our advanced technological platforms and a range of capabilities. Our team differentiates ourselves based on a strong commitment to innovative solutions and quality R&D for our partners.

Tempo Bioscience Support

On Demand Custom Engineered Cell Models

Tempo develops patient relevant stem cell (iPSCs) based models to support drug discovery, preclinical studies, and early-stage clinical development.